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导师简介

魏 伟 博士 简介

信息来源:本站原创发布日期: 2014-11-06浏览次数:

   

魏伟男,山东枣庄人,1982年9月出生,博士,副教授,山东省首批优秀青年基金获得者(省优青),目前,在加拿大麦吉尔大学访学。2005年毕业于聊城大学化学与化工学院,获得理学学士学位。2008年毕业于四川大学化学学院,获得理学硕士学位。2012年获得中国科学院成都生物研究所药物化学博士学位。 2012年7月至今 曲阜师范大学化学与化工学院从事教学科研工作。2012年11月作为核心成员加入“泰山学者”王桦教授科研创新团队。 2012年12月获曲阜师范大学优秀博士计划支持。2015年1月晋升副教授。 近年来一直致力于绿色合成化学和药物化学方面的研究工作,在Angew. Chem. Int. Ed, Green chemistry, Chem Commun, Advanced Synthesis & Catalysis, Journal of organic chemistry, Organic Chemistry Frontiers 等国际知名学术杂志上发表SCI论文40余篇。第一作者或通讯作者SCI论文20余篇,IF总和超过100,被引用次数300余次;申请国家发明专利3项。2012年获中国科学院院长奖学金;2013山东省微课教学比赛一等奖;2013全国微课教学比赛三等奖;2014年曲阜师范大学青年教师教学比赛三等奖;2014年获得山东省高等学校优秀科研成果奖三等奖(首位); 获得山东省自然科学学术创新奖二等奖(首位);获得第四届济宁市自然科学学术创新奖一等奖(首位);2015年获得山东省高等学校优秀科研成果奖三等奖(第二位)。

主要工作经历:

  2005/09-2008/06,四川大学,化学学院,硕士,专业:有机化学

  2008/09-2012/06,中国科学院成都生物研究所,天然产物中心,博士,专业:药物化学

  2008/09-2012/06 成都地奥制药集团新药研究所,新药实习研究人员

  2012/07-2014/12 曲阜师范大学化学与化工学院, 讲师

  2012/11-至今“泰山学者”王桦教授科研创新团队核心成员

  2015/01-至今 曲阜师范大学化学与化工学院,副教授

主要研究领域为“绿色合成化学和药物化学”。科学目标是:1)开展绿色化学研究,为药物制造提供高效的合成工具;2)建立创新药物发现工作系统,以先导化合物的发现、合成与优化为关键点,在抗癌、抗肿瘤等重大疾病治疗领域展开药物创新研究。近年来在基础研究领域具体开展以下研究工作: 1)研究直接利用氧气和简单商品化的原料构建重要的含氧化合物,探讨其催化氧化反应机理。2)研究新型、高效非金属催化及水相合成药物中间体的方法,为药物分子合成提供了简单、绿色、便捷的途径。3)研究高原子经济性、多组分串联反应合成结构复杂多样的小分子化合物,为类药物先导化合物的发现提供重要的化合物来源和筛选平台近期发表代表性文章如下:

[1] Wei Wei, Jian-Xin Ji,* Catalytic and Direct Oxyphosphorylation of Alkenes with Dioxygen and H-Phosphonates Leading to b-KetophosphonatesAngew. Chem. Int. Ed. 2011, 50, 9097-9099. (IF = 11.734).

[2] Wei Wei, Xiao-Yu Hu, Xiao-Wei Yan, Qiang Zhang, Ming Cheng, Jian-Xin Ji.* Direct use of dioxygen as an oxygen source: catalytic oxidative synthesis of amides, Chemical Communications, 2012, 8, 305-307. (IF = 6.718) .

[3] Wei Wei, Chunli Liu, Daoshan Yang, Jiangwei Wen, Jinmao You, Yourui Suo, Hua Wang.* Copper-catalyzed direct oxysulfonylation of alkenes with dioxygen and sulfonylhydrazides leading to b-ketosulfones, Chemical Communications.2013, 49, 10239-10241.(IF = 6.718) .

[4] Wei Wei, Jiangwei Wen, Daoshan Yang, Juan Du, Jinmao You, Hua Wang,* Catalyst-free direct arylsulfonylation of N-arylacrylamides with sulfinic acids: a convenient and efficient route to sulfonated oxindoles, Green Chemistry, 2014, 16, 2988-2991. (IF = 8.02)

[5] Wei Wei, Jiangwei Wen, Daoshan Yang, Xiaoxia Liu, Mengyuan Guo, Ruimei Dong, Hua Wang,* Metal-Free Direct Trifluoromethylation of Activated Alkenes with Langlois’ Reagent Leading to CF3- Containing Oxindoles, Journal of Organic Chemistry, 2014, 79, 4225−4230. (IF = 4.638) .

[6] Wei Wei, Jiangwei Wen, Daoshan Yang, Mengyuan Guo, Yingying Wang, Jinmao You, Hua Wang*, Direct and metal-free arylsulfonylation of alkynes with sulfonylhydrazides for the construction of 3-sulfonated coumarins, Chemical Communications, 2015, 51, 768-771.(IF = 6.718)

[7] Wei Wei, Chunli Liu, Daoshan Yang, Jiangwei Wen, Jinmao You, Hua Wang*. “Metal Free Direct Construction of Sulfonamides via Iodine Mediated Coupling Reaction of Sodium Sulfinates and Amines at Room Temperature”, Advanced Synthesis & Catalysis. 2015, 357, 987-992 (IF = 5.542)

[8] Jiangwei Wen, Wei Wei,* Shengnan Xue, Daoshan Yang, Yu Lou, Chaoyang Gao, Hua Wang*, Metal-free Oxidative Spirocyclization of Alkynes with Sulfonylhydrazides leading to 3-Sulfonated Azaspiro[4,5]trienones, Journal of Organic Chemistry, 2015, 80, 4966−4972 (IF = 4.638).

[9]Wei Wei, Jiangwei Wen, Daoshan Yang, Xuejun Sun, Jinmao You, Yourui Suo, Hua Wang.* Iron-catalyzed three-component tandem process: a nove land convenient synthetic route to quinoline-2,4-dicarboxylates from arylamines,glyoxylic esters, and a-ketoesters Tetrahedron, 2013, 69, 10747-10751 (IF = 2.802).

[10] Wei Wei, Jiangwei Wen, Daoshan Yang, Huijun Jing, Jinmao You, Hua Wang*. Direct difunctionalization of alkynes with sulfinic acids and molecular iodine: a simple and convenient approach to (E)-β-iodovinyl sulfones, RSC Advance., 2015, 45, 4416-4419.IF =3.708

[11] Wei Wei, Jinli Li, Daoshan Yang, Jiangwei Wen,Yueting Jiao, Jinmao You, Hua Wang.* Copper-catalyzed highly selective direct hydrosulfonylation of alkynes with arylsulfinic acids leading to vinyl sulfones, Organic Biomolecular Chemistry, 2014, 12, 1861–1864. (IF = 3.478)

[12] Wei Wei, Jiangwei Wen, Daoshan Yang, Min Wu,Jinmao You and Hua Wang, *Iron-catalyzed direct difunctionalization of alkenes with dioxygen and sulfinic acids: a highly efficient and green approach toβ-ketosulfones, Organic Biomolecular Chemistry, 2014, 14, 7678. (IF = 3.478)

[13] Wei Wei, Jiangwei Wen, Daoshan Yang, Mengyuan Guo, Laijin Tian, Jinmao You, Hua Wang*, Copper-catalyzed cyanoalkylarylation of activated alkenes with AIBN: a convenientand efficient approach to cyano-containing oxindoles, RSC Advance., 2014, 4, 48535-48538.

[14] Wei Wei, Xiaoxia Liu, Daoshan Yang, Ruimei Dong, Ying Cui, Fei Yuan, Hua Wang*Direct difunctionalization of alkenes with sulfinic acids and NBS leading to b-bromo sulfones, Tetrahedron Letters2015, 56, 1808-1811.(IF = 2.6)

[15] Jiangwei Wen,Wei Wei*, Daoshan Yang, Yufeng Fan, Lulu Fu, Hua Wang*. Metal-Free Direct Hydrosulfonylation of Azodicarboxylates with Sulfinic Acids Leading to Sulfonylhydrazine Derivatives, Synthetic Commun.,2015, 45: 1574–1584.

[16] Chunli Liu, Minghui Zhu,Wei Wei*, Daoshan Yang, Hong Cui, Xiaoxia Liu, Hua Wang*, Metal-free direct difunctionalization of alkenes with I2Oand P(O)–H compounds leading to β-iodophosphates, Organic Chemistry Frontiers, 2015, 2, 1356-1360.

[17] Chunli Liu,WeiWei*, DaoshanYang,Yuanyuan Zheng,Yanshuai Bi,Min Chen, HuaWang*. I2O5/DBU mediated direct-phosphoryloxylation of ketones with H-phosphonates leading to-hydroxyketone phosphates. Tetrahedron, 2015, 71, 6901-6906.

[18]Huanhuan Cui, Wei Wei,* Daoshan Yang,Jimei Zhang,Zhihong Xu,Jiangwei Wen, Hua Wang*. Silver-catalyzed direct spirocyclization of alkynes with thiophenols: a simple and facile approach to 3-thioazaspiro[4,5]trienones. RSC Advances, 2015, 5, 84657-84661

[19] Wei Wei, Yuancheng Qin, Meiming Luo, Pingfang Xia, Man Shing Wong, Synthesis, Structure, and Catalytic Activity of Palladium(II) Complexes of New CNC Pincer-Type N-Heterocyclic Carbene Ligands, Organometallics. 2008, 27, 2268-2272. (IF=3.963)